Design and synthesis of a biotinylated dopamine transporter ligand for the purification and labeling of dopaminergic neurons

Bioorg Med Chem Lett. 1998 Feb 3;8(3):261-6. doi: 10.1016/s0960-894x(98)00003-1.

Abstract

The design and synthesis of a new tool for labeling and purification of dopaminergic neurons is described.

MeSH terms

  • Animals
  • Biotin / analogs & derivatives*
  • Biotin / chemical synthesis
  • Biotin / chemistry
  • Biotin / metabolism
  • Carrier Proteins / metabolism*
  • Cells, Cultured
  • Dopamine / metabolism*
  • Dopamine Plasma Membrane Transport Proteins
  • Ligands
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Membrane Glycoproteins*
  • Membrane Transport Proteins*
  • Mesencephalon / cytology
  • Mesencephalon / embryology
  • Mesencephalon / metabolism
  • Nerve Tissue Proteins*
  • Neurons / cytology*
  • Neurons / metabolism
  • Piperazines / chemical synthesis
  • Piperazines / chemistry*
  • Piperazines / metabolism
  • Rats

Substances

  • CGP 81077
  • Carrier Proteins
  • Dopamine Plasma Membrane Transport Proteins
  • Ligands
  • Membrane Glycoproteins
  • Membrane Transport Proteins
  • Nerve Tissue Proteins
  • Piperazines
  • Biotin
  • Dopamine